Gina Kolata

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The Walking Dead - Season 2, Episode 1 - Photo Credit: Gene Page/AMC - DSC_0111phgn_R_Ph_Gene_Page

Some people aren’t polite about their drug addictions, and some of us are rude in return. They’re called names, like “crackheads.” How messy that such substances are purchased on streets. When these folks are minorities, the meanest among us assign blame to them based on race. It’s appalling and counterproductive. 

I’ve thought for the past decade that white Americans of what used to be called the middle class have a very polite and well-mannered drug epidemic in oxycodone and the like. The whole undertaking is as neat and clean as a prescription pad. Reports of a spiked usage would regularly be published, but I worried that maybe I suffered from confirmation bias because I’ve spent so much time visiting relatives in hospitals the last few years. In these facilities, it’s easy to assume an oxy epidemic. The same goes for other self-destructive behaviors (obesity, alcoholism, etc.) appearing to be rampant.

It’s worth wondering how much opioid use is causing the alarming trend in the U.S. of the increasing deaths in white, middle-aged citizens, which has just been reported in a stunning paper by Anne Case and Angus Deaton. Why are people in this group drugging, eating and drinking themselves to death? Why have they become the walking dead? Some of it is overt suicide, some buried in risky behaviors.

From Gina Kolata of the New York Times:

The mortality rate for whites 45 to 54 years old with no more than a high school education increased by 134 deaths per 100,000 people from 1999 to 2014.

“It is difficult to find modern settings with survival losses of this magnitude,” wrote two Dartmouth economists, Ellen Meara and Jonathan S. Skinner, in a commentary to the Deaton-Case analysis to be published in Proceedings of the National Academy of Sciences.

“Wow,” said Samuel Preston, a professor of sociology at the University of Pennsylvania and an expert on mortality trends and the health of populations, who was not involved in the research. “This is a vivid indication that something is awry in these American households.”

Dr. [Angus] Deaton had but one parallel. “Only H.I.V./AIDS in contemporary times has done anything like this,” he said. …

David M. Cutler, a Harvard health care economist, said that although it was known that people were dying from causes like opioid addiction, the thought was that those deaths were just blips in the health care statistics and that over all everyone’s health was improving. The new paper, he said, “shows those blips are more like incoming missiles.”•

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I got the flu a number of years ago while reading Gina Kolata’s excellent book about the 1918 influenza pandemic, but I’m not pointing fingers. The opening of “Power in Numbers,” her new New York Times profile of Eric Lander, a brilliant mathematician who made the unlikely career switch to genome-mapping without the benefit of a biology background:

“His Ph.D. is in pure mathematics, in a subfield so esoteric and specialized that even if someone gets a great result, it can be appreciated by only a few dozen people in the entire world. But he left that world behind and, with no formal training, entered another: the world of molecular biology, medicine and genomics.ounding director of the Broad Institute of Harvard and M.I.T., he heads a biology empire and raises money from billionaires. He also teaches freshman biology (a course he never took) at M.I.T., advises President Obama on science and runs a lab.

Eric Lander — as a friend, Prof. David Botstein of Princeton, put it — knows how to spot and seize an opportunity when one arises. And he has another quality, says his high school friend Paul Zeitz: bravery combined with optimism.

‘He was super smart, but so what?’ said Dr. Zeitz, now a mathematics professor at the University of San Francisco. ‘Pure intellectual heft is like someone who can bench-press a thousand pounds. But so what, if you don’t know what to do with it?’

Eric Lander, he added, knew what to do. And he knew how to carry out strong ideas about where progress in medicine will come from — large interdisciplinary teams collaborating rather than single researchers burrowed in their labs.

So how did he end up at the Broad Institute, going from the most solitary of sciences to forging new sorts of collaborations in a field he never formally studied? What sort of person can make that journey?

Dr. Lander’s story can be told as a linear narrative of lucky breaks and perfect opportunities. But he doesn’t subscribe to that sort of magical thinking. To him, biography is something of a confection: ‘You live your life prospectively and tell your story retrospectively, so it looks like everything is converging.'”

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Back to the 1918 flu pandemic for a moment: “Grotesque and ugly in their influenza masks, the people of San Francisco celebrate.”

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