David Ewing Duncan

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Imagine healthy, aging people experimenting with synthetic biology to prevent deterioration, replacing their own cells with inviolable, indefatigable ones. From a Technology Review Q&A conducted by David Ewing Duncan with geneticist George Church, whose new book is entitled Regenesis:

Technology Review:

When is regeneration likely to happen in humans?

George Church:

There is much to be worked out. But here’s the leap. If you want to accelerate this, you have to pick an intermediate target that doesn’t sound so scary. So you’ll start out with bone marrow patients. And you’re going to basically make a synthetic version of that patient’s bone marrow using IPS, which is going to work much better than the diseased bone marrow. And once this works that’s going to catch on like wildfire. And then you’ll do skin, and then you’ll do every other stem cell you can get.

Technology Review:

Who is going to do this?

George Church:

The only way people are going to get this is through some brave soul. It will start with a sick person, and they will end up getting well, possibly more well than before they got sick. So you didn’t just correct the sickness, you actually did more. And they’ll give testimonials, and someone from the New York Times will interview them, and tell this appealing anecdote.

Technology Review:

Will people who are, say, aging but not yet sick ever be able to use this technology?

George Church:

I don’t consider this medicine, it’s preventive. I expect somebody who is truly brave, who has nothing wrong with them other than maybe the usual aging, saying: ‘I want a bone marrow transplant’, or intestinal, or whatever. And it will gain momentum from there.” (Thanks Next Big Future.)

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The United States ranks 34th in infant mortality rate, but some of us dream of life-extension beyond belief, we dream of an end that never arrives. That’s our strange reality right now, though perhaps the Affordable Care Act will improve those numbers, should it survive one more mad charge in November. From David Ewing Duncan in the New York Times:

“How many years might be added to a life? A few longevity enthusiasts suggest a possible increase of decades. Most others believe in more modest gains. And when will they come? Are we a decade away? Twenty years? Fifty years?

Even without a new high-tech ‘fix’ for aging, the United Nations estimates that life expectancy over the next century will approach 100 years for women in the developed world and over 90 years for women in the developing world. (Men lag behind by three or four years.)

Whatever actually happens, this seems like a good time to ask a very basic question: How long do you want to live?

Over the past three years I have posed this query to nearly 30,000 people at the start of talks and lectures on future trends in bioscience, taking an informal poll as a show of hands. To make it easier to tabulate responses I provided four possible answers: 80 years, currently the average life span in the West; 120 years, close to the maximum anyone has lived; 150 years, which would require a biotech breakthrough; and forever, which rejects the idea that life span has to have any limit at all.”

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From “A Little Device Trying to Read Your Thoughts,” David Ewing Duncan’s New York Times article about Stephen Hawking adopting the iBrain:

“Already surrounded by machines that allow him, painstakingly, to communicate, the physicist Stephen Hawking last summer donned what looked like a rakish black headband that held a feather-light device the size of a small matchbox.

Called the iBrain, this simple-looking contraption is part of an experiment that aims to allow Dr. Hawking — long paralyzed by amyotrophic lateral sclerosis, or Lou Gehrig’s disease — to communicate by merely thinking.

The iBrain is part of a new generation of portable neural devices and algorithms intended to monitor and diagnose conditions like sleep apnea, depression and autism. Invented by a team led by Philip Low, a 32-year-old neuroscientist who is chief executive of NeuroVigil, a company based in San Diego, the iBrain is gaining attention as a possible alternative to expensive sleep labs that use rubber and plastic caps riddled with dozens of electrodes and usually require a patient to stay overnight.

‘The iBrain can collect data in real time in a person’s own bed, or when they’re watching TV, or doing just about anything,’ Dr. Low said.”

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Main title music by Philip Glass for Errol Morris’ 1991 Hawking film:

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