“We Are Entering An Era In Which It Will Not Be Chance That Configures DNA”


If performance-enhancing drugs weren’t at all dangerous to the athletes using them, should they be banned?

I bet plenty of people would say they should, bowing before some notion of competitive purity which has never existed. It’s also a nod to “god-given ability,” a curious concept in an increasingly agnostic world. Why should those born with the best legs and lungs be the fastest? Why should the ones lucky enough to have the greatest gray matter at birth be our best thinkers? Why should those fortunate to initially get the healthiest organs live the longest? It doesn’t make much sense to hold back the rest of the world out of respect for a few winners of the genetics lottery.

Stephen Hsu, who had a Nautilus piece included on Afflictor’s 2015 “50 Great Articles Online for Free” list, has penned for that publication another excellent essay: “We Are Nowhere Close to the Limits of Athletic Performance.” It relates how genetic engineering will supercharge athletes and the rest of us, making widely available the gifts of Usain Bolt, who gained his from hard work, sure, but also a twist of fate. In fact, extrapolating much further, Hsu believes “speciation seems a definite possibility.”

An excerpt about CRISPR:

[George] Church has also been involved in one of the greatest scientific breakthroughs of recent decades: the development of a highly efficient gene editing tool called CRISPR, which has been approved for clinical trials for medical applications. If CRISPR-related technologies develop as anticipated, designer humans are at most a few decades away. Editing is most easily done soon after conception, when the embryo consists of only a small number of cells, but it is also possible in adults. Clinical trials of CRISPR, when they start this year, will edit existing cells in adults using an injection of a viral vector. It seems likely that CRISPR, or some improved version of it, will be established to be both safe and effective in the near future.

Because complex traits are controlled by so many variants, we know that there is a huge pool of untapped potential that no human—not Shaq, Bolt, or anyone else—has come close to exhausting. No living human has anywhere near all of the possible positive versions of the relevant genetic variants. The whole enterprise of competitive athletics has been, in effect, a search algorithm for genetic outliers, but it’s been running for less than a century, and it hasn’t been particularly efficient. Its approach has been to passively wait for random recombinations to produce those variants, and hope that athletic programs find the best individuals.

Now we are entering an era in which it will not be chance that configures DNA, but rather the human intellect via tools of its own creation. As our understanding of complex traits improves, genetic engineers will be able to modify strength, size, explosiveness, endurance, quickness, speed, and even the determination and drive required for extensive athletic training.•

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